Cod cathelicidin: isolation of the mature peptide, cleavage site characterisation and developmental expression.

@article{Broekman2011CodCI,
  title={Cod cathelicidin: isolation of the mature peptide, cleavage site characterisation and developmental expression.},
  author={Daniela C Broekman and Dominik Michael Frei and Gudj{\'o}n Andri Gylfason and Agnar Steinarsson and Hans J{\"o}rnvall and Birgitta Agerberth and Gudmundur Hrafn Gudmundsson and Valerie Helene Maier},
  journal={Developmental and comparative immunology},
  year={2011},
  volume={35 3},
  pages={296-303}
}
Cathelicidin antimicrobial peptides are multifunctional peptides that are important in the innate immune system of mammals. Cathelicidins have been identified in several fish species. In this study we have isolated cathelicidin from Atlantic cod (Gadus morhua) and identified the cleavage site from the cathelin propart. This is the first isolation of a cathelicidin from teleost fish. The mature cathelicidin was found to be a 67-residues peptide, highly cationic with a pI of 13. Reversed phase… CONTINUE READING

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