Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells

@article{Bacac2004CoculturesOM,
  title={Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells},
  author={Marina Bacac and Marta Vadori and Gianni Sava and Sabrina Pacor},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={53},
  pages={1101-1110}
}
The effects of NAMI-A, [H2im][trans-RuCl4(dmso-S)(Him)], a new metal-based agent for treating tumor metastases, have been investigated in vitro on splenocytes, ConA- or LPS-activated T and B lymphoblasts, and thymocytes. Splenocytes and thymocytes exposed for 1 h to 0.01–0.1-mM NAMI-A do not change their mitochondrial functionality, cell cycle distribution, protein synthesis, and CD44 expression in comparison to untreated control samples. Instead, mitochondrial functionality increased 24 h… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Intra-tumoral NAMI-A treatment triggers metastasis reduction, which correlates to CD44 regulation and TIL recruitment

  • S Pacor, M Cocchietto, +5 authors G Sava
  • J PET (in press)
  • 2004
Highly Influential
4 Excerpts

CD 44 ligation on peripheral

  • G Sconocchia, L Campagnano, +4 authors CU Casciani
  • BLOOD
  • 2001

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