Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells

@article{Bacac2004CoculturesOM,
  title={Cocultures of metastatic and host immune cells: selective effects of NAMI-A for tumor cells},
  author={M. Bacac and M. Vadori and G. Sava and S. Pacor},
  journal={Cancer Immunology, Immunotherapy},
  year={2004},
  volume={53},
  pages={1101-1110}
}
  • M. Bacac, M. Vadori, +1 author S. Pacor
  • Published 2004
  • Biology, Medicine
  • Cancer Immunology, Immunotherapy
  • The effects of NAMI-A, [H2im][trans-RuCl4(dmso-S)(Him)], a new metal-based agent for treating tumor metastases, have been investigated in vitro on splenocytes, ConA- or LPS-activated T and B lymphoblasts, and thymocytes. Splenocytes and thymocytes exposed for 1 h to 0.01–0.1-mM NAMI-A do not change their mitochondrial functionality, cell cycle distribution, protein synthesis, and CD44 expression in comparison to untreated control samples. Instead, mitochondrial functionality increased 24 h… CONTINUE READING

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