Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

@article{Marcotrigiano1997CocrystalSO,
  title={Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP},
  author={Joseph Marcotrigiano and Anne-Claude Gingras and Nahum Sonenberg and Stephen K. Burley},
  journal={Cell},
  year={1997},
  volume={89},
  pages={951-961}
}
The X-ray structure of the eukaryotic translation initiation factor 4E (eIF4E), bound to 7-methyl-GDP, has been determined at 2.2 A resolution. eIF4E recognizes 5' 7-methyl-G(5')ppp(5')N mRNA caps during the rate-limiting initiation step of translation. The protein resembles a cupped hand and consists of a curved, 8-stranded antiparallel beta sheet, backed by three long alpha helices. 7-methyl-GDP binds in a narrow cap-binding slot on the molecule's concave surface, where 7-methyl-guanine… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 242 CITATIONS

FILTER CITATIONS BY YEAR

1998
2018

CITATION STATISTICS

  • 38 Highly Influenced Citations

  • Averaged 11 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

The effect of “cap” analogs on reovirus mRNA

  • A. J. kin
  • 1978
Highly Influential
7 Excerpts

mRNA 59 Cap-binding protein eIF4E

  • N. Sonenberg
  • 1996
Highly Influential
4 Excerpts

An essential E motif KSGST

  • A. Rustgi, L. Callanan, E. V. Schmidt
  • J. Biol
  • 1996

Similar Papers

Loading similar papers…