Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

@article{Marcotrigiano1997CocrystalSO,
  title={Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP},
  author={J. Marcotrigiano and Anne-Claude Gingras and N. Sonenberg and S. Burley},
  journal={Cell},
  year={1997},
  volume={89},
  pages={951-961}
}
  • J. Marcotrigiano, Anne-Claude Gingras, +1 author S. Burley
  • Published 1997
  • Medicine, Biology
  • Cell
  • The X-ray structure of the eukaryotic translation initiation factor 4E (eIF4E), bound to 7-methyl-GDP, has been determined at 2.2 A resolution. eIF4E recognizes 5' 7-methyl-G(5')ppp(5')N mRNA caps during the rate-limiting initiation step of translation. The protein resembles a cupped hand and consists of a curved, 8-stranded antiparallel beta sheet, backed by three long alpha helices. 7-methyl-GDP binds in a narrow cap-binding slot on the molecule's concave surface, where 7-methyl-guanine… CONTINUE READING
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