Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2.

@article{Kenny2004CocoaPI,
  title={Cocoa procyanidins inhibit proliferation and angiogenic signals in human dermal microvascular endothelial cells following stimulation by low-level H2O2.},
  author={Thomas P. Kenny and Carl L. Keen and Peter L. Jones and Hsing-Jien Kung and Harold H. Schmitz and M Eric Gershwin},
  journal={Experimental biology and medicine},
  year={2004},
  volume={229 8},
  pages={
          765-71
        }
}
Procyanidins extracted from cocoa play a role in the defense against oxidative stress, as well as in vascular and immune functions. We previously reported that pentameric procyanidins isolated from cocoa inhibit the expression of the tyrosine kinase ErbB2 gene, thus slowing the growth of cultured human aortic endothelial cells. We herein investigate the further consequences of such inhibition by cocoa procyanidins, particularly regarding the protein level in phosphorylation patterns and the… CONTINUE READING

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