Cocoa Phytochemicals: Recent Advances in Molecular Mechanisms on Health

@article{Kim2014CocoaPR,
  title={Cocoa Phytochemicals: Recent Advances in Molecular Mechanisms on Health},
  author={Jiyoung Kim and Jaekyoon Kim and Jaesung Shim and Chang Yong Lee and Ki Won Lee and Hyong Joo Lee},
  journal={Critical Reviews in Food Science and Nutrition},
  year={2014},
  volume={54},
  pages={1458 - 1472}
}
Recent reports on cocoa are appealing in that a food commonly consumed for pure pleasure might also bring tangible benefits for human health. Cocoa consumption is correlated with reduced health risks of cardiovascular diseases, hypertension, atherosclerosis, and cancer, and the health-promoting effects of cocoa are mediated by cocoa-driven phytochemicals. Cocoa is rich in procyanidins, theobromine, (−)-epicatechin, catechins, and caffeine. Among the phytochemicals present in consumed cocoa… Expand
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Impact of cocoa flavanols on human health.
  • M. Martín, S. Ramos
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2021
TLDR
This review summarizes human studies from the past two decades, providing data related to the effects derived from cocoa intake on health and disease and identifying different mechanisms of action for cocoa, although they are not fully understood at present. Expand
Cocoa Bioactive Compounds: Significance and Potential for the Maintenance of Skin Health
TLDR
In vivo studies showing that bioactive compounds of cocoa may have a positive impact on skin health are summarized, emphasizing potential cytoprotective pathways modulated by cocoa and its polyphenolic components. Expand
Protective effects of tea, red wine and cocoa in diabetes. Evidences from human studies.
  • M. Martín, L. Goya, S. Ramos
  • Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2017
TLDR
Overall observational data suggest a benefit, but results are still equivocal and likely confounded by lifestyle and background dietary factors, so it remains uncertain whether tea, red wine and cocoa consumption is recommended to the general population or to patients as a strategy to reduce the risk of diabetes. Expand
Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin
TLDR
This review presents a research overview conducted on some plants and vegetables frequently consumed by humans, whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay. Expand
The Impact of Cocoa Flavanols on Cardiovascular Health
TLDR
Chocolate products marketed for their purported health benefits should therefore declare the amounts of total flavanols and epicatechin, and cocoa flavanol doses of around 900 mg or above may decrease blood pressure in specific individuals and/or if consumed over longer periods. Expand
Cocobiota: Implications for Human Health
TLDR
Various metabolites produced by cocobiota can mimic some medicinal effects of dark chocolate and other cocoa-derived products previously attributed to cocoa flavonoids and methylxanthines and need to be thoroughly investigated in in vitro and in vivo systems. Expand
Managing hypertension by polyphenols.
TLDR
Whether and how limitations of scientific knowledge, data derived from large randomized clinical trials, and an accurate assessment of the bioactive components provided by common foodstuff may complicate the extensive use of plant-derived products in the management of hypertension are discussed. Expand
Antidiabetic actions of cocoa flavanols.
TLDR
Insight is provided into the molecular machinery of the chemopreventive activity of cocoa and its flavanols by compiling cell culture and animal models studies, as well as evidence from human interventional trials. Expand
Cardioprotection by Cocoa Polyphenols and ω-3 Fatty Acids: A Disease-Prevention Perspective on Aging-Associated Cardiovascular Risk
TLDR
The purpose of this review is to summarize the major cardioprotective effects of CPs and ω-3 fatty acids, providing a scientific rationale for incorporating the combination of these molecules as a nutritional intervention in the prevention of CVD. Expand
An overview on the role of plant-derived tannins for the treatment of lung cancer.
TLDR
In vivo and in vitro studies provide evidences that anti-cancer effects of various tannins are predominantly mediated through negative regulation of transcription factors, growth factors, receptor kinases, and many oncogenic molecules. Expand
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