Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects.

@article{Furuya2000CockroachDH,
  title={Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects.},
  author={Kaoru Furuya and R J Milchak and Kathleen M. Schegg and Jin Rui Zhang and Stephen S. Tobe and Geoff M Coast and David A. Schooley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 12},
  pages={6469-74}
}
Insect diuretic hormones are crucial for control of water balance. We isolated from the cockroach Diploptera punctata two diuretic hormones (DH), Dippu-DH(31) and Dippu-DH(46), which increase cAMP production and fluid secretion in Malpighian tubules of several insect species. Dippu-DH(31) and -DH(46) contain 31 and 46 amino acids, respectively. Dippu-DH(46) belongs to the corticotropin-releasing factor (CRF)-like insect DH family, whereas Dippu-DH(31) has little sequence similarity to the CRF… CONTINUE READING