5 Citations
Connecting the Dots: From DNA Damage and Repair to Aging
- BiologyInternational journal of molecular sciences
- 2016
The connection between DDR and DNA repair and aging is reviewed and the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging are discussed.
In Search for Biomarkers of Aging : A Proteomics Approach
- Biology
- 2006
Data clearly show that during replicative senescence changes occur at the protein level that could influence cellular and consequently tissue functionality, which could provide an environment for the development of age-associated diseases like atherosclerosis.
The role of insulin and IGF-1 signaling in longevity
- PhysicsCellular and Molecular Life Sciences CMLS
- 2004
The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling and histone deacetylases of the SIR family in a complex interaction to influence lifespan is studied.
References
SHOWING 1-3 OF 3 REFERENCES
Cockayne syndrome and xeroderma pigmentosum
- Medicine, BiologyNeurology
- 2000
The paradoxical lack of parallelism of phenotype to genotype is unexplained in these disorders, and diverse mutations responsible for UV sensitivity and deficient DNA repair may also produce profound failure of brain and somatic growth, progressive cachexia and premature aging.