Cockayne Syndrome

@article{Mallory2003CockayneS,
  title={Cockayne Syndrome},
  author={Susan Bayliss Mallory and Bernice R. Krafchik and Matthew M. Bender and Lorraine Potocki and Denise W Metry},
  journal={Pediatric Dermatology},
  year={2003},
  volume={20}
}
Connecting the Dots: From DNA Damage and Repair to Aging
TLDR
The connection between DDR and DNA repair and aging is reviewed and the potential mechanisms by which deficient DNA repair triggers systemic effects to promote physiological or pathological aging are discussed.
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Data clearly show that during replicative senescence changes occur at the protein level that could influence cellular and consequently tissue functionality, which could provide an environment for the development of age-associated diseases like atherosclerosis.
The role of insulin and IGF-1 signaling in longevity
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The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling and histone deacetylases of the SIR family in a complex interaction to influence lifespan is studied.

References

SHOWING 1-3 OF 3 REFERENCES
Cockayne syndrome and xeroderma pigmentosum
TLDR
The paradoxical lack of parallelism of phenotype to genotype is unexplained in these disorders, and diverse mutations responsible for UV sensitivity and deficient DNA repair may also produce profound failure of brain and somatic growth, progressive cachexia and premature aging.
Cockayne syndrome: review of 25 cases.
Ocular findings in Cockayne syndrome.