Cochrane Systematic Review of Colorectal Cancer Screening Using the Fecal Occult Blood Test (Hemoccult): An Update

@article{Hewitson2008CochraneSR,
  title={Cochrane Systematic Review of Colorectal Cancer Screening Using the Fecal Occult Blood Test (Hemoccult): An Update},
  author={Paul Hewitson and Paul P. Glasziou and Eila K Watson and Bernie Towler and Les M. Irwig},
  journal={The American Journal of Gastroenterology},
  year={2008},
  volume={103},
  pages={1541-1549}
}
BACKGROUND AND AIMS:Reducing mortality from colorectal cancer (CRC) may be achieved by the introduction of population-based screening programs. The aim of the systematic review was to update previous research to determine whether screening for CRC using the fecal occult blood test (FOBT) reduces CRC mortality and to consider the benefits, harms, and potential consequences of screening.METHODS:We searched eight electronic databases (Cochrane Library, MEDLINE, EMBASE, CINAHL, PsychINFO, AMED… 

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References

SHOWING 1-10 OF 71 REFERENCES

Screening for colorectal cancer using the faecal occult blood test, Hemoccult.

Whether screening for colorectal cancer using the faecal occult blood test (guaiac or immunochemical) reduces coloreCTal cancer mortality and to consider the benefits, harms and potential consequences of screening is reviewed.

Reduction in colorectal cancer mortality by fecal occult blood screening in a French controlled study.

It is suggested that biennial screening by FOBTs can reduce CRC mortality regardless of the quality of the health system and support attempts to introduce large-scale screening programs into the general population.

Does Fecal Occult Blood Testing Really Reduce Mortality? A Reanalysis of Systematic Review Data

The impact of FOBT in reducing mortality from any cause is uncertain and efficacy of this strategy for CRC screening needs reevaluation.

A randomised study of screening for colorectal cancer using faecal occult blood testing: results after 13 years and seven biennial screening rounds

The persistent reduction in mortality from CRC in a biennial screening program with Hemoccult-II, and a reduction in RR to less than 0.70 in those adhering to the programme, support attempts to introduce larger scale population screening programmes.

Effect of faecal occult blood screening on mortality from colorectal cancer: results from a randomised controlled trial

There was a 13% reduction in colorectal cancer mortality in the intervention group despite an uptake at first invitation of only approximately 50% and further follow up of this population is required to determine whether a significant reduction in the incidence of coloreCTal cancer will be achieved.

Colorectal cancer screening: scientific review.

The recommendation that all men and women aged 50 years or older undergo screening for colorectal cancer is supported by a large body of direct and indirect evidence, but the available evidence does not currently support choosing one test over another.

Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study.

Cutting mortality in the annually screened group was accompanied by improved survival in those with colorectal cancer and a shift to detection at an earlier stage of cancer.

Fecal occult blood screening for colorectal cancer.

The fecal occult blood test remains a workable approach to reducing the mortality from colorectal cancer provided it is carried out with attention to important variables such as the need for compliance, including the compliance of physicians.

The effect of fecal occult-blood screening on the incidence of colorectal cancer.

The use of either annual or biennial fecal occult-blood testing significantly reduces the incidence of colorectal cancer.
...