Cochlear pharmacokinetics of cisplatin: an in vivo study in the guinea pig.

Abstract

OBJECTIVES/HYPOTHESIS Cisplatin produces toxic lesions to outer hair cells (OHCs) in the cochlear base but not in the apex. The objective of this study was to compare the pharmacokinetic profile of cisplatin in scala tympani (ST) perilymph in the cochlear base and apex, respectively. STUDY DESIGN In vivo animal study. METHODS Forty-seven guinea pigs… (More)
DOI: 10.1002/lary.24235

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@article{Hellberg2013CochlearPO, title={Cochlear pharmacokinetics of cisplatin: an in vivo study in the guinea pig.}, author={Victoria Hellberg and Inger Wallin and H Henrik Ehrsson and G{\"o}ran Laurell}, journal={The Laryngoscope}, year={2013}, volume={123 12}, pages={3172-7} }