Cochlear outer hair cell motility.

@article{Ashmore2008CochlearOH,
  title={Cochlear outer hair cell motility.},
  author={Jonathan F Ashmore},
  journal={Physiological reviews},
  year={2008},
  volume={88 1},
  pages={
          173-210
        }
}
  • J. Ashmore
  • Published 2008
  • Biology
  • Physiological reviews
Normal hearing depends on sound amplification within the mammalian cochlea. The amplification, without which the auditory system is effectively deaf, can be traced to the correct functioning of a group of motile sensory hair cells, the outer hair cells of the cochlea. Acting like motor cells, outer hair cells produce forces that are driven by graded changes in membrane potential. The forces depend on the presence of a motor protein in the lateral membrane of the cells. This protein, known as… 
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References

SHOWING 1-10 OF 376 REFERENCES

Prestin is the motor protein of cochlear outer hair cells

It is concluded that prestin is the motor protein of the cochlear outer hair cell, which is specifically expressed in outer hair cells that express prestin.

Molecular mechanisms of sound amplification in the mammalian cochlea.

It is shown here that outer hair cells selectively take up fructose, at rates high enough to suggest that a sugar transporter may be part of the motor complex.

Fast motility of isolated mammalian auditory sensory cells.

Motility-associated hair-bundle motion in mammalian outer hair cells

The OHCs showed bundle movement with peak responses of up to 830 nm, which suggests that the bundle movement originated in somatic motility and that somatic Motility has a central role in cochlear amplification in mammals.

Motility of cochlear outer hair cells.

The mechanism underlying the shape changes induced by different stimuli are discussed, and the role of fast and slow motility in the physiology and pathology of auditory transduction is assessed.

How well do we understand the cochlea?

Somatic stiffness of cochlear outer hair cells is voltage-dependent.

  • D. HeP. Dallos
  • Biology, Engineering
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
It is shown that the cylindrical outer hair cells change their axial stiffness as their membrane potential is altered and this change is accompanied by mechanical reactance changes of the cells.

Hair-Cell Mechanotransduction and Cochlear Amplification

Stereocilia displacement induced somatic motility of cochlear outer hair cells.

  • B. EvansP. Dallos
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1993
It is shown here that mechanically induced hair-bundle deflection produces somatic motility of the cell, indicating that the cell may possess capabilities to affect its mechanical environment under control of its own receptor potential and, thereby, participate in a local cochlear feedback process.

Active hair bundle movements in auditory hair cells

Evidence for active hair bundle motion and its connection to MT channel adaptation is summarized and key factors for the hair bundle motor to play a role in the mammalian cochlea include the size and speed of force production.
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