Coccoid like forms (CLF) of Helicobacter pylori. Enzyme activity and antigenicity.

  title={Coccoid like forms (CLF) of Helicobacter pylori. Enzyme activity and antigenicity.},
  author={M. Nilius and Andreas Str{\"o}hle and Gũnter Bode and P Malfertheiner},
  journal={Zentralblatt fur Bakteriologie : international journal of medical microbiology},
  volume={280 1-2},
In this study we attempted to transform "helical" forms of Helicobacter pylori to "coccoid like forms" (CLF) by induction with the following substances in vitro: bismuth subcitrate, bismuth subsalicylate, ampicillin, amoxicillin, erythromycin, ursodeoxycholic acid and glycochenodeoxycholic acid. Some liquid cultures were incubated for 24 days to induce CLF by aging. Changes in the protein pattern, urease enzyme activity and in the serological response against specific antigens were investigated… CONTINUE READING


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