Cocatalytic zinc motifs in enzyme catalysis.

  title={Cocatalytic zinc motifs in enzyme catalysis.},
  author={Bert L. Vallee and Douglas S Auld},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 7},
Cocatalytic zinc binding sites are characteristic of enzyme molecules which contain two or more zinc and/or other metal atoms. In each site an aspartate, glutamate, or histidine residue simultaneously binds to two zinc atoms or a zinc and a different metal atom. In the resultant amino acid bridge, two of the cocatalytic metal atoms bind to the same amino acid. Consequently the participating metal atoms are in close proximity and function as a catalytic unit, typical of this motif. In these… CONTINUE READING

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