Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development.

@article{Lozano2014CocarcinogenicEO,
  title={Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development.},
  author={Esther Corral Lozano and Laura Sanchez-Vicente and Mar{\'i}a Jes{\'u}s Monte and Elisa Herraez and {\'O}scar Briz and Jes{\'u}s Mar{\'i}a Banales and Jose J G Marin and Rocio I. R. Macias},
  journal={Molecular cancer research : MCR},
  year={2014},
  volume={12 1},
  pages={
          91-100
        }
}
UNLABELLED Bile acid accumulation in liver with cholangiolar neoplastic lesions may occur before cholestasis is clinically detected. Whether this favors intrahepatic cholangiocarcinoma development has been investigated in this study. The E. coli RecA gene promoter was cloned upstream from Luc2 to detect in vitro direct genotoxic ability by activation of SOS genes. This assay demonstrated that bile acids were not able to induce DNA damage. The genotoxic effect of the DNA-damaging agent cisplatin… CONTINUE READING

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