Cocaine withdrawal produces behavioral disruptions in rats.

@article{Carroll1987CocaineWP,
  title={Cocaine withdrawal produces behavioral disruptions in rats.},
  author={Marilyn Carroll and Sylvie T. Lac},
  journal={Life sciences},
  year={1987},
  volume={40 22},
  pages={
          2183-90
        }
}
There is currently no laboratory or clinical evidence from animal or human studies documenting a withdrawal syndrome associated with cocaine dependence, although many users report that withdrawal disturbances are responsible for their repeated use of the drug. In the present study rats self-administered i.v. cocaine and a sweetened drinking solution. When cocaine access was terminated there was a marked suppression in operant behavior reinforced by the sweetened solution, and this withdrawal… CONTINUE READING

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