Cocaine use and cardiovascular complications

  title={Cocaine use and cardiovascular complications},
  author={Gabriella Vasica and Christopher Tennant},
  journal={Medical Journal of Australia},
In Australia, the lifetime use of cocaine is rising, with 3% of the population aged over 14 using cocaine in 1991, increasing to 4.5% in 1998, and cocaine use accounting for 10% of all deaths secondary to illicit drug use in 1998. Cocaine is prepared from the leaves of the plant Erythroxylon coca, and is available as cocaine hydrochloride (a water‐soluble powder or granule which can be taken orally, intravenously or intranasally) and as “freebase” or “crack” cocaine (heat stable, melting at… 

Acute cocaine toxicity: assessment and cardiac risk

The aim of this article is to highlight the presentation and consequence of acute cocaine toxicity in relatio...

Data available on the extent of cocaine use and dependence: biochemistry, pharmacologic effects and global burden of disease of cocaine abusers.

The effects of Cocaine mainly depend on the user's addiction, the dose received and the mode of assumption, so ascribing adverse health effect to a certain drug might be difficult.

Peripartum care of the cocaine‐abusing parturient: are we ready?

  • K. Kuczkowski
  • Medicine, Psychology
    Acta obstetricia et gynecologica Scandinavica
  • 2005
Several agents are discussed briefly that have been proposed for the treatment of chest pain and other cardiovascular side‐effects of cocaine toxicity in pregnancy and their mechanism of action is considered.

Acute aortic dissection associated with use of cocaine.

Anesthesia in patients who are users of crack and cocaine

Anesthesia in drug dependent patients is a real challenge to the anesthesiologist who must therefore be aware of the pathophysiological alterations to best address these patients and decrease morbidity and mortality.

The risk for mild kidney function decline associated with illicit drug use among hypertensive men.

Interventions aimed at helping patients discontinue illicit drug use and maintain a drug-free lifestyle may have an important role in delaying and/or preventing the onset of kidney disease in hypertensive men.

Reverse Takotsubo Cardiomyopathy Precipitated by Chronic Cocaine and Cannabis Use.

In this case, multiple insults including severe headache, cannabis hyperemesis and cocaine and methamphetamine-induced serotonin toxicity culminated in a drug-induced seizure which led to catecholamine cardiotoxicity resulting in rTC.

Acute myocardial infarction following the combined use of cocaine and alcohol.

A 37-year-old man who presented with inferior wall myocardial infarction shortly after the concomitant use of cocaine and ethanol showed prompt ST resolution after thrombolytic therapy andCoronary angiography showed normal coronary arteries.

Non-fatal cocaine overdose among injecting and non-injecting cocaine users in Sydney, Australia.

Cocaine users need to be aware of the possibility and nature of overdose, and that cocaine overdose can occur irrespective of method of use, and there is a need to emphasise the potential danger of combining cocaine with other drugs.



The management of cocaine-associated myocardial ischemia.

  • J. Hollander
  • Medicine, Biology
    The New England journal of medicine
  • 1995
The use of cocaine has reached epidemic proportions. Over 30 percent of men and 20 percent of women between the ages of 26 and 34 have used cocaine at least once.1 Moreover, 23 million Americans have

Triggering of myocardial infarction by cocaine.

Cocaine use is associated with a large abrupt and transient increase in the risk of acute myocardial infarction in patients who are otherwise at relatively low risk, and this finding suggests that studying the pathophysiological changes produced by cocaine may provide insights into the mechanisms by which myocardials is triggered by other stressors.

Cocaine-Associated Myocardial Infarction: Mortality and Complications

The mortality of patients hospitalized with cocaine-associated myocardial infarction was low and the majority of complications occurred within 12 hours of presentation, including congestive heart failure and brady-dysrhythmias.

Cocaine activates platelets and increases the formation of circulating platelet containing microaggregates in humans

The view that cocaine, even at the relatively low doses commonly self administered by occasional abusers, may promote thrombosis and predispose healthy individuals to ischaemic events is supported.

Cocaine stimulates the human cardiovascular system via a central mechanism of action.

These studies provide direct microneurographic evidence in humans that intranasal cocaine stimulates central sympathetic outflow and appears to be targeted not only to the cutaneous circulation promoting peripheral vasoconstriction but also to the heart promoting tachycardia.

Risk of acute myocardial infarction in cocaine abusers.

  • T. Cheng
  • Medicine, Psychology
  • 2000
To the Editor: I read with interest but some skepticism the article on the triggering of myocardial infarction by cocaine by Mittleman et al.1 They reported that in the first hour after cocaine

Cardiovascular complications of cocaine.

Cocaine increases the endothelial release of immunoreactive endothelin and its concentrations in human plasma and urine: reversal by coincubation with sigma-receptor antagonists.

It is suggested that cocaine increases the endothelin-1 release in vitro and in vivo and may prove to play a role in vasospastic angina, acute myocardial infarction, and sudden cardiac death.