Cocaine sensitization in periadolescent and adult rats.

@article{Laviola1995CocaineSI,
  title={Cocaine sensitization in periadolescent and adult rats.},
  author={Giovanni Laviola and Robin D. Wood and Cynthia M. Kuhn and Reynold Francis and Linda Patia Spear},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={275 1},
  pages={345-57}
}
Periadolescent rats have been reported to be affected differentially by catecholaminergic agents when compared with younger or adult animals. The present study evaluated the behavioral responsivity of periadolescent (34- to 39-day-old) and adult (60- to 70-day-old) Sprague-Dawley rats of both sexes to i.p. cocaine (Coc) administration (0, 10 or 20 mg/kg, once daily for 4 days). All animals received injections of both saline and Coc every day paired with a different context, with one-half of the… CONTINUE READING
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