Cocaine self-administration produces a persistent increase in dopamine D2 High receptors.

@article{Briand2008CocaineSP,
  title={Cocaine self-administration produces a persistent increase in dopamine D2 High receptors.},
  author={Lisa A Briand and Shelly B. Flagel and Philip Seeman and Terry E. Robinson},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2008},
  volume={18 8},
  pages={551-6}
}
Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors. However, in rodents, repeated cocaine administration consistently produces hypersensitivity to the psychomotor activating effects of both indirect dopamine agonists, such as cocaine itself, and importantly, to direct-acting D2 receptor agonists. The current study reports a possible resolution to this long-standing paradox. The dopamine D2 receptor exists in both a low and a high-affinity state, and… CONTINUE READING