Cocaine self-administration produces a persistent increase in dopamine D2 High receptors.


Cocaine addicts are reported to have decreased numbers of striatal dopamine D2 receptors. However, in rodents, repeated cocaine administration consistently produces hypersensitivity to the psychomotor activating effects of both indirect dopamine agonists, such as cocaine itself, and importantly, to direct-acting D2 receptor agonists. The current study… (More)
DOI: 10.1016/j.euroneuro.2008.01.002


3 Figures and Tables