Cocaine self-administration in rats: threshold procedures.

  title={Cocaine self-administration in rats: threshold procedures.},
  author={Erik B. Oleson and David C. S. Roberts},
  journal={Methods in molecular biology},
Cocaine self-administration provides a methodology allowing researchers to study changes in distinct aspects of drug-taking behavior that model behaviors observed in drug addicts. Traditionally, self-administration schedules were designed to independently study changes in drug-taking behaviors (e.g., rate of responding, reinforcing efficacy, etc.). The threshold self-administration procedure was developed to measure two distinct dependent measures within the same experimental session that are… CONTINUE READING