Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition.

@article{Host2011CocaineSA,
  title={Cocaine self-administration alters the expression of chromatin-remodelling proteins; modulation by histone deacetylase inhibition.},
  author={Lionel Host and Jan Hendrik Dietrich and Delphine Carouge and Dominique Aunis and Jean Zwiller},
  journal={Journal of psychopharmacology},
  year={2011},
  volume={25 2},
  pages={
          222-9
        }
}
Injection of the histone deacetylases inhibitor trichostatin A to rats has been shown to decrease the reinforcing properties of cocaine. In the present study, we investigated alterations in gene expression patterns in the anterior cingulate cortex, caudate-putamen and nucleus accumbens of rats self-administering cocaine and treated with trichostatin A. As recent studies highlighted the importance of chromatin remodelling in the regulation of gene transcription in neurons, we studied the… CONTINUE READING
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