Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.

@article{Sora1998CocaineRM,
  title={Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.},
  author={Ichiro Sora and Christine H Wichems and Nobuyuki Takahashi and X F Li and Zhao-ling Zeng and Robert Revay and Klaus-Peter Lesch and Dennis L. Murphy and George R. Uhl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 13},
  pages={7699-704}
}
Cocaine and methylphenidate block uptake by neuronal plasma membrane transporters for dopamine, serotonin, and norepinephrine. Cocaine also blocks voltage-gated sodium channels, a property not shared by methylphenidate. Several lines of evidence have suggested that cocaine blockade of the dopamine transporter (DAT), perhaps with additional contributions from serotonin transporter (5-HTT) recognition, was key to its rewarding actions. We now report that knockout mice without DAT and mice without… CONTINUE READING
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