Cocaine-related sudden cardiac death: a hypothesis correlating basic science and clinical observations.

@article{Bauman1994CocainerelatedSC,
  title={Cocaine-related sudden cardiac death: a hypothesis correlating basic science and clinical observations.},
  author={Jerry L Bauman and Johannes Grawe and A P Winecoff and Robert J Hariman},
  journal={Journal of clinical pharmacology},
  year={1994},
  volume={34 9},
  pages={902-11}
}
Sudden, unexpected death due to cocaine in young otherwise healthy individuals occurs in an idiosyncratic manner and is commonly felt to be arrhythmogenic in nature, although the exact cause of death is rarely documented. In addition to indirect sympathomimetic actions, cocaine is a potent sodium channel blocking drug and, in this regard, most closely resembles agents such as flecainide. We suggest that sudden death due to cocaine is proarrhythmic in nature, occurring under similar… CONTINUE READING

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