Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area

@article{Mameli2011CocaineIR,
  title={Cocaine inverts rules for synaptic plasticity of glutamate transmission in the ventral tegmental area},
  author={Manuel Mameli and Camilla Bellone and Matthew T. C. Brown and Christian L{\"u}scher},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={414-416}
}
The manner in which drug-evoked synaptic plasticity affects reward circuits remains largely elusive. We found that cocaine reduced NMDA receptor excitatory postsynaptic currents and inserted GluA2–lacking AMPA receptors in dopamine neurons of mice. Consequently, a stimulation protocol pairing glutamate release with hyperpolarizing current injections further strengthened synapses after cocaine treatment. Our data suggest that early cocaine-evoked plasticity in the ventral tegmental area inverts… CONTINUE READING

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