Cocaine induces DNA damage in distinct brain areas of female rats under different hormonal conditions

  title={Cocaine induces DNA damage in distinct brain areas of female rats under different hormonal conditions},
  author={Marilise Fraga de Souza and Tierre A Gonçales and Aline Steinmetz and Dinara Jaqueline Moura and Jenifer Saffi and Rosane Gomez and Helena M. T. Barros},
  journal={Clinical and Experimental Pharmacology and Physiology},
We evaluated levels of neuronal DNA damage after acute or repeated cocaine treatment in different brain areas of female rats after ovariectomy or sham surgery. Rats in the control and acute groups were given saline i.p., whereas in the repeated group were given 15 mg/kg, i.p., cocaine for 8 days. After a 10 day washout period, the control group was given saline i.p., whereas rats in the acute and repeated groups were given a challenge dose of 15 mg/kg, i.p., cocaine. After behavioural… 
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