Cocaine-induced myocardial ischemia and infarction: pathophysiology, recognition, and management.

@article{Pitts1997CocaineinducedMI,
  title={Cocaine-induced myocardial ischemia and infarction: pathophysiology, recognition, and management.},
  author={William Reid Pitts and Richard A. Lange and Joaquin E. Cigarroa and Leslie David Hillis},
  journal={Progress in cardiovascular diseases},
  year={1997},
  volume={40 1},
  pages={65-76}
}
As cocaine abuse has become widespread, it has been associated with various cardiovascular complications, including angina pectoris, myocardial infarction, and sudden cardiac death. Cocaine's principal effects on the cardiovascular system are mediated via alpha-adrenergic stimulation and include (1) an increase in the determinants of myocardial oxygen demand (heart rate and systemic arterial pressure), and (2) a concomitant decrease in myocardial oxygen supply (caused by vasoconstriction of the… CONTINUE READING
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