Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptors.

@article{Jayaram2006CocaineinducedII,
  title={Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptors.},
  author={Prathiba Jayaram and Jeffery D. Steketee},
  journal={European journal of pharmacology},
  year={2006},
  volume={531 1-3},
  pages={74-9}
}
A recent study showed that cocaine-induced sensitization is associated with an increase in GABA (gamma-aminobutyric acid) transmission in the medial prefrontal cortex. Since previous studies have demonstrated that sensitization is associated with enhanced medial prefrontal cortex glutamatergic transmission, the present study examined the role of N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate (AMPA/KA) receptors in cocaine-induced increases in… CONTINUE READING