Cocaine-induced breakdown of the blood-brain barrier and neurotoxicity.

@article{Sharma2009CocaineinducedBO,
  title={Cocaine-induced breakdown of the blood-brain barrier and neurotoxicity.},
  author={Hari Shanker Sharma and Dafin Fior Mureșanu and Aruna Sharma and Ranjana Patnaik},
  journal={International review of neurobiology},
  year={2009},
  volume={88},
  pages={
          297-334
        }
}
Role of cocaine in influencing blood-brain barrier (BBB) function is still unknown. Available evidences suggest that cocaine administration results in acute hyperthermia and alterations in brain serotonin metabolism. Since hyperthermia is capable to induce the breakdown of the BBB either directly or through altered serotonin metabolism, a possibility exists that cocaine may induce neurotoxicity by causing BBB disruption. This hypothesis is discussed in this review largely based on our own… CONTINUE READING
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