Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A.

@article{Mattson2005CocaineinducedCP,
  title={Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A.},
  author={Brandi J. Mattson and Jennifer M Bossert and Danielle E. Simmons and Naohito Nozaki and Deepti R. Nagarkar and Justin D Kreuter and Bruce T Hope},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 5},
  pages={1481-94}
}
Repeated cocaine administration to rats outside their home cages sensitizes the behavioral effects of the drug, and enhances induction of the immediate early gene product Fos in nucleus accumbens. We hypothesized that the same treatment regimen would also enhance cocaine-induced activation of intracellular signaling kinases that phosphorylate cyclic AMP-regulated element-binding protein (CREB), an important mediator of c-fos transcription. Phosphorylation levels of extracellular signal… CONTINUE READING
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