Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects.

@article{Du2006CocaineIT,
  title={Cocaine increases the intracellular calcium concentration in brain independently of its cerebrovascular effects.},
  author={Congwu Du and Mei Yu and Nora D. Volkow and Alan P. Koretsky and Joanna S. Fowler and Helene Benveniste},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 45},
  pages={11522-31}
}
Cocaine abuse increases the risk of life-threatening neurological complications such as strokes and seizures. Although the vasoconstricting properties of cocaine underlie its cerebrovascular effects, the mechanisms underlying its neurotoxicity remain incompletely understood. Here, we use optical techniques to measure cerebral blood volume, hemoglobin oxygenation (S(t)O(2)), and intracellular calcium ([Ca(2+)](i)) to test the hypothesis that cocaine increases [Ca(2+)](i) in the brain. The… CONTINUE READING
21 Citations
78 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

pocampal neurons in vitro and in vivo

  • JH Lee, FW Telang, CS Springer, ND Volkow
  • 2003
Highly Influential
8 Excerpts

Neural correlates of high and

  • AS Bloom, H Garavan, EA Stein
  • 2005

Similar Papers

Loading similar papers…