Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis

@article{McGregor1992CocaineFO,
  title={Cocaine facilitation of prefrontal cortex self-stimulation: a microstructural and pharmacological analysis},
  author={Iain S McGregor and Dale M. Atrens and David M. Jackson},
  journal={Psychopharmacology},
  year={1992},
  volume={106},
  pages={239-247}
}
A novel self-stimulation methodology involving a fixed-interval (FI-5 s) schedule of reinforcement, microanalysis and threshold evaluation was used to investigate the effects of cocaine on rats lever pressing for electrical stimulation of the prefrontal cortex. Cocaine (15 mg/kg) increased medial prefrontal cortex (MPC) self-stimulation rates under FI-5 by a mean of 269% and reduced current thresholds for self-stimulation. A similar facilitation was evident with self-stimulation of the sulcal… CONTINUE READING

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