Cocaine excretion in the semen of drug users.

@article{Cone1996CocaineEI,
  title={Cocaine excretion in the semen of drug users.},
  author={Edward J. Cone and K. Kato and M J Hillsgrove},
  journal={Journal of analytical toxicology},
  year={1996},
  volume={20 2},
  pages={
          139-40
        }
}
The belief that cocaine has aphrodisiac properties has prevailed among drug users for decades. Cocaine use is frequently linked with stimulated sexual behavior; addicts often rate cocaine as the most effective drug for increasing libido and sexual responsiveness. Animal studies with radiolabeled cocaine indicate that the drug is deposited in genital and extragenital organs, including the epididymis and seminal vesicles (1). Specific binding sites have been characterized on human spermatozoa (2… 

Tables from this paper

Drug testing with alternative matrices I. Pharmacological effects and disposition of cocaine and codeine in plasma, sebum, and stratum corneum.
TLDR
No definitive relationship was observed between drug concentrations in sebum and stratum corneum compared with dose and the mechanism(s) for deposition of cocaine and codeine appeared to be complex and could involve the transfer of drugs between different body fluids and other matrices.
Subtle biobehavioral effects produced by paternal cocaine exposure
TLDR
The presence of a subtle but significant increase in immobility in the tail suspension test, a measure of behavioral depression, following paternal cocaine is reported, which suggests alterations in brain systems and/or circuitry underlying mood regulation in the offspring of cocaine‐using fathers.
Cocaine and Its Variations in Forms of Presentation and Addiction
This chapter intends to show cocaine variations in its forms of presentation, chemical forms, pharmacology, use forms, and contexts of use to understand how these factors can influence drug
[Cocaine and pregnancy].
Does paternal occupation and lifestyle affect embryo quality
TLDR
Man is exposed to numerous exogenous as well as environmental chemicals through various routes, and exposure to chemical contaminants, which are estrogen mimics and endocrine disruptors, has been implicated as one of the possible factors contributing to the increasing male infertility.
Cigarette smoking and its toxicological overview on human male fertility—a prospective review
TLDR
The aim of this review is to elucidate the smoking impact on semen parameters, reactive oxidative species (ROS) state, cigarette toxicity marker, and in detail how it is affecting semenogelin/chromatin structure by cadmium as one of the cigarette toxicants.
Lifestyle factors in deteriorating male reproductive health.
TLDR
The data available suggests that lifestyle factors such as obesity, tobacco smoking or chewing, alcohol and some of the illicit drugs like cocaine, cannabis etc and exposure to extreme heat, have adverse effects on male reproduction.
Toxicology in Reproductive Endocrinology.
Evaluation of genotoxicity of pan masala employing chromosomal aberration and micronucleus assay in bone marrow cells of the mice
TLDR
Both types of pan masala, i.e. plain and gutkha, have genotoxic potential, and dose-dependent, significant increase in chromosome aberration was observed in both types ofPan masala treated mice with respect to control, and no significant difference in micronucleus and chromosomal aberration induction was noticed between two types ofpan masala exposed groups.
...
...

References

SHOWING 1-10 OF 15 REFERENCES
Pharmacokinetics and pharmacodynamics of cocaine.
  • E. Cone
  • Psychology, Biology
    Journal of analytical toxicology
  • 1995
TLDR
It is demonstrated that cocaine administration by the smoked route produced substantially higher behavioral responses than an equivalent dose of cocaine administered by the intravenous route, and this finding suggests that smoked cocaine (crack) has a higher abuse liability and greater dependence-producing properties than equivalent doses of cocaineadministered byThe intravenous or intranasal route.
Distribution of tritiated cocaine in selected genital and nongenital organs following administration to male mice
TLDR
Radioactivity is distributed to several organs, including the genital tract, and is found in association with sperm after in vivo administration of tritiated cocaine, and it is raised a possibility that the spermatozoa may carry cocaine into the oocyte during fertilization.
Distribution of tritiated cocaine in selected genital and nongenital organs following administration to male mice.
TLDR
Radioactivity is distributed to several organs, including the genital tract, and is found in association with sperm after in vivo administration of tritiated cocaine, and a possibility that the spermatozoa may carry cocaine into the oocyte during fertilization is raised.
Demonstration of specific binding of cocaine to human spermatozoa.
TLDR
The hypothesis that the sperm may act as a vector to transport cocaine into an ovum is supported and this novel mechanism could be involved in the abnormal development of offspring of cocaine-exposed males.
Effects of cocaine hydrochloride on reproductive function and sexual behavior of male rats and on the behavior of their offspring.
TLDR
Administration of cocaine resulted in dose-related decreases in body weights, increases in locomotor activity, and decreases in estradiol levels, and the high dose of cocaine was associated with an increase in the percentage of spermatozoa with heads separated from tails.
Drugs in Semen
TLDR
It may be advisable to include, in the processes of drug development, pharmacokinetic evaluation of a drug in the semen and analysis of standard microscopic parameters of the semen, particularly important for drugs known to concentrate in the sperm.
Learning achievement in sons of alcoholics.
TLDR
Cognitive impairment may be associated with the vulnerability for alcoholism and the highest and most numerous correlations were found between neuropsychological performance and educational achievement.
Effects of Paternal Exposure to Alcohol on Offspring Development
  • T. Cicero
  • Medicine
    Alcohol health and research world
  • 1994
Paternal alcohol consumption may affect fetal development through a direct effect on the father’s sperm or gonads. This possibility casts new light on the heritability of alcoholism in humans.
Specific cognitive impairment in sons of early onset alcoholics.
TLDR
Sons of early onset alcoholics performed more poorly than offspring of the normal fathers on tests measuring attention and verbal intellectual capacity, but were not significantly different from sons of late onset alcoholic fathers.
...
...