Cocaine effects on the developing brain: current status

  title={Cocaine effects on the developing brain: current status},
  author={J. Harvey},
  journal={Neuroscience & Biobehavioral Reviews},
  • J. Harvey
  • Published 2004
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • The present paper reports on the results obtained in a rabbit model of prenatal cocaine exposure that mimics the pharmacokinetics of crack cocaine in humans, and relates these findings to studies in other species including humans. A general finding is that prenatal exposure to cocaine during neurogenesis produces dysfunctions in signal transduction via the dopamine D(1) receptor and alterations in cortical neuronal development leading to permanent morphological abnormalities in frontocingulate… CONTINUE READING
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