Cocaine effects on behavioral responding to a novel object placed in a familiar environment

  title={Cocaine effects on behavioral responding to a novel object placed in a familiar environment},
  author={Robert J. Carey and Ernest N. Damianopoulos and Arielle B. Shanahan},
  journal={Pharmacology Biochemistry and Behavior},
Cocaine conditioned behavior: A cocaine memory trace or an anti-habituation effect
Behavior selectively elicited by novel stimuli: modulation by the 5-HT1A agonist 8-OHDPAT and antagonist WAY-100635
Findings provide evidence for an involvement of the serotonergic system in the response to novel stimuli and indicate that this effect can be dissociated from effects on overall activity including locomotor, rearing and grooming behaviors.
What's conditioned in conditioned place preference?
Changes in emotional behavior produced by orexin microinjections in the paraventricular nucleus of the thalamus
Dopamine receptor activity participates in hippocampal synaptic plasticity associated with novel object recognition
The results indicate that DA‐receptor signaling contributes to the successful completion of the NOR task and to the associated synaptic plasticity of the dentate gyrus that likely contributesto the learning.
A neurorobotic platform to test the influence of neuromodulatory signaling on anxious and curious behavior
The present neurorobotic experiments can lead to a better understanding of how neuromodulatory signaling affects the balance between anxious and curious behavior, and may be informative in exploring a wide range of neurological diseases such as anxiety, autism, attention deficit disorders, and obsessive-compulsive disorders.
Subsequent behavioural development of offspring exposed to methadone during gestation, lactation or both
The significant longer term effects of earlier methadone on the rats’ behavioural development supported the need for more research into this hitherto relatively neglected area, and could be useful for understanding potential risk factors in the ever growing methADone-exposed population, and thus suggesting best practice for Methadone maintenance programmes.
Design Principles for Neurorobotics
In their book “How the Body Shapes the Way We Think: A New View of Intelligence,” Pfeifer and Bongard put forth an embodied approach to cognition. Because of this position, many of their robot


Cocaine conditioning and sensitization: The habituation factor
Independence of amphetamine reward from locomotor stimulation demonstrated by conditioned place preference
It is shown that rats can demonstrate a CPP produced by amphetamine even when their activity is restrained, which suggests that the drug's rewarding properties are not dependent on locomotor stimulation.
State-dependent peculiarities of cocaine-induced behavioral sensitization and their possible reasons.
  • E. Kiyatkin
  • Biology, Psychology
    The International journal of neuroscience
  • 1992
Reinforcing action of COC determining development of interinfluence of its effects and ones triggered by environmental variables (learning based on conditioning) is considered as a proposed initial cause and a main mechanism for enhanced reactivity to cocaine administered under conditions of its previous use and to various environmental events associated with previous cocaine effects.
Cocaine-induced place conditioning: importance of route of administration and other procedural variables
The results show PPC procedure to be a valid test for evaluating rewarding properties of IV cocaine, however, they fail to show rewarding effects of IP cocaine.
The NMDA antagonist MK-801 can impair attention to exteroceptive stimuli