Cocaine dependence: a disease of the brain's reward centers.

  title={Cocaine dependence: a disease of the brain's reward centers.},
  author={Charles A. Dackis and Charles P O'brien},
  journal={Journal of substance abuse treatment},
  volume={21 3},
Cocaine addiction affects brain reward centers that have evolved to ensure survival. Cocaine euphoria is intensely pleasurable and results from mesolimbic dopamine (DA) neurotransmission. DA signal-receiving neurons in the nucleus accumbens synthesize endogenous opioids and project to numerous reward regions. Cocaine-induced neuroadaptations, including DA depletion, may underlie craving and hedonic dysregulation. Cue-induced craving is vigorously triggered by conditioned elements of the drug… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
86 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 86 extracted citations

Similar Papers

Loading similar papers…