Cocaine dependence: a disease of the brain's reward centers.

@article{Dackis2001CocaineDA,
  title={Cocaine dependence: a disease of the brain's reward centers.},
  author={Charles A. Dackis and Charles P O'brien},
  journal={Journal of substance abuse treatment},
  year={2001},
  volume={21 3},
  pages={111-7}
}
Cocaine addiction affects brain reward centers that have evolved to ensure survival. Cocaine euphoria is intensely pleasurable and results from mesolimbic dopamine (DA) neurotransmission. DA signal-receiving neurons in the nucleus accumbens synthesize endogenous opioids and project to numerous reward regions. Cocaine-induced neuroadaptations, including DA depletion, may underlie craving and hedonic dysregulation. Cue-induced craving is vigorously triggered by conditioned elements of the drug… CONTINUE READING
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