Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs.

@article{Daunais1995CocaineBD,
  title={Cocaine binges differentially alter striatal preprodynorphin and zif/268 mRNAs.},
  author={James B. Daunais and Jacqueline F McGinty},
  journal={Brain research. Molecular brain research},
  year={1995},
  volume={29 2},
  pages={201-10}
}
Several studies have demonstrated that cocaine increases preprodynorphin, c-fos, and zif/268 mRNAs in rat dorsal striatum. Multiple, closely spaced exposures to cocaine appear to elicit the greatest increases in dynorphin. However, the response of preproenkephalin, c-fos and zif/268 mRNAs to such a dosing regimen is unknown. Therefore, we used a 'binge' paradigm to evaluate changes in mRNA for preprodynorphin, preproenkephalin, c-fos and zif/268. Male Wistar rats received three hourly i.p… CONTINUE READING
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