Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects

@article{Carroll1990CocainebaseSI,
  title={Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects},
  author={Marilyn Carroll and Kelly L. Krattiger and Daniel Gieske and Daniel A. Sadoff},
  journal={Psychopharmacology},
  year={1990},
  volume={102},
  pages={443-450}
}
Four rhesus monkeys were trained to smoke cocaine-base under a progressive ratio (PR) schedule, with ten smoking trials available each day. Unit dose was varied from 0.25 to 3 mg/kg, and lidocaine (2 mg/kg) was substituted for cocaine. Number of responses and break-point on the PR schedule increased with dose while the number of smoke deliveries increased only slightly. Maximum daily smoke deliveries ranged from six to nine across monkeys. When lidocaine (2 mg/kg) was substituted for cocaine… CONTINUE READING
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