Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model.

@article{Roth2005CocaineAS,
  title={Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model.},
  author={Michael D Roth and Katherine M Whittaker and Ruth Choi and Donald P Tashkin and Gayle Cocita Baldwin},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 6},
  pages={1198-203}
}
Cocaine is associated with an increased risk for, and progression of, clinical disease associated with human immunodeficiency virus (HIV) infection. A human xenograft model, in which human peripheral blood mononuclear cells were implanted into severe combined immunodeficiency mice (huPBL-SCID) and infected with a HIV reporter virus, was used to investigate the biological interactions between cocaine and HIV infection. Systemic administration of cocaine (5 mg/kg/d) significantly increased the… CONTINUE READING

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Cocaine modulates cytokine balance and enhances tumor growth through receptors

  • B. Gardner, L. X. Zhu, M. D. Roth, D. P. Tashkin, S. M. Dubinett, S. Sharma
  • J. Neuroimmunol
  • 2004
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