Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.

@article{Izenwasser1993CocaineAS,
  title={Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen.},
  author={S. E. Izenwasser and Amy Hauck Newman and Jonathan Katz},
  journal={European journal of pharmacology},
  year={1993},
  volume={243 2},
  pages={201-5}
}
Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse. 

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…