Cocaine and phencyclidine inhibition of the acetylcholine receptor: analysis of the mechanisms of action based on measurements of ion flux in the millisecond-to-minute time region.

@article{Karpen1982CocaineAP,
  title={Cocaine and phencyclidine inhibition of the acetylcholine receptor: analysis of the mechanisms of action based on measurements of ion flux in the millisecond-to-minute time region.},
  author={Jeffrey W. Karpen and Hitoshi Aoshima and Leo G. Abood and George P. Hess},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1982},
  volume={79 8},
  pages={2509-13}
}
The effects of cocaine and of phencyclidine and procaine on acetylcholine receptor-controlled ion flux were measured in the millisecond-to-minute time region. Chemical kinetic measurements of ion flux were made in membrane vesicles prepared from the electric organ of Electrophorus electricus and in PC-12 cells, a sympathetic neuronal cell line. A quench-flow technique was used to measure ion flux in the millisecond-to-second range in membrane vesicles. Cocaine and phencyclidine both inhibit… CONTINUE READING

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