Cocaine and metabolite concentrations in plasma during repeated oral administration: development of a human laboratory model of chronic cocaine use.

@article{Jufer1998CocaineAM,
  title={Cocaine and metabolite concentrations in plasma during repeated oral administration: development of a human laboratory model of chronic cocaine use.},
  author={R. Jufer and S. Walsh and E. Cone},
  journal={Journal of analytical toxicology},
  year={1998},
  volume={22 6},
  pages={
          435-44
        }
}
  • R. Jufer, S. Walsh, E. Cone
  • Published 1998
  • Medicine, Chemistry
  • Journal of analytical toxicology
  • Long-term use of cocaine may produce neurophysiological and metabolic alterations that differ from acute drug use. A laboratory model that was capable of evaluating the effects of chronic cocaine administration in human subjects was needed. Chronic oral administration of cocaine was considered a feasible route because of the ease of administration, control of dosing patterns, and possible reduction in medical risks compared with the intravenous and smoked routes. This clinical study was… CONTINUE READING
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