Cocaine and heroin (‘speedball’) self-administration: the involvement of nucleus accumbens dopamine and μ-opiate, but not δ-opiate receptors

@article{Cornish2004CocaineAH,
  title={Cocaine and heroin (‘speedball’) self-administration: the involvement of nucleus accumbens dopamine and μ-opiate, but not δ-opiate receptors},
  author={Jennifer Louise Cornish and Jaclyn M. Lontos and Kelly J Clemens and Iain S McGregor},
  journal={Psychopharmacology},
  year={2004},
  volume={180},
  pages={21-32}
}
The combined administration of heroin and cocaine (‘speedball’) is common among intravenous drug users. Dopamine receptors in the nucleus accumbens play a key role in cocaine self-administration; however, their role in speedball self-administration is unknown, as is the role of opiate receptors in this region. The effect of blocking dopamine D1, D2, μ-opiate or δ-opiate receptors in the nucleus accumbens on the intravenous self-administration of combined heroin and cocaine was examined in rats… CONTINUE READING

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