Cocaine- and amphetamine-regulated transcript activates the hypothalamic-pituitary-adrenal axis through a corticotropin-releasing factor receptor-dependent mechanism.

@article{Smith2004CocaineAA,
  title={Cocaine- and amphetamine-regulated transcript activates the hypothalamic-pituitary-adrenal axis through a corticotropin-releasing factor receptor-dependent mechanism.},
  author={Sean M. Smith and Joan M. Vaughan and Cynthia J. Donaldson and Jean E F Rivier and Chien – Yi Li and Alon Chen and Wylie W. Vale},
  journal={Endocrinology},
  year={2004},
  volume={145 11},
  pages={5202-9}
}
Cocaine- and amphetamine-regulated transcript (CART) is a highly expressed hypothalamic transcript that is concentrated in areas associated with the stress response. There is evidence for a role of CART in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis. However, it is not clear whether CART regulates activity of the HPA axis by directly stimulating ACTH release from pituitary corticotropes or through interaction with hypothalamic factors. To address this issue, the effects of… CONTINUE READING

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