Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons

@article{Jedynak2016CocaineAA,
  title={Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons},
  author={Jakub Jedynak and Matthew C. Hearing and Anna E. Ingebretson and Stephanie R. Ebner and Matthew Kelly and Rachel A. Fischer and Sa{\"i}d Kourrich and Mark J Thomas},
  journal={Neuropsychopharmacology},
  year={2016},
  volume={41},
  pages={464-476}
}
Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote drug-seeking and -taking behavior. In rodent addiction models, persistent changes in excitatory glutamatergic neurotransmission in the nucleus accumbens (NAc) appear to drive this drug-induced behavioral plasticity. To study whether changes in glutamatergic signaling are shared between or exclusive to specific psychostimulant drugs, we examined synaptic transmission from mice following repeated amphetamine or… CONTINUE READING

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Synaptic transmission mediated by AMPA - type glutamate receptors was potentiated in the NAc shell 10–14 days following repeated amphetamine or cocaine treatment .
Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote drug - seeking and -taking behavior .
This synaptic enhancement was depotentiated by re - exposure to amphetamine or cocaine .
By contrast , in the NAc core only repeated cocaine exposure enhanced synaptic transmission , which was subsequently depotentiated by an additional cocaine but not amphetamine injection during drug abstinence .
By contrast , in the NAc core only repeated cocaine exposure enhanced synaptic transmission , which was subsequently depotentiated by an additional cocaine but not amphetamine injection during drug abstinence .
Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons .
To study whether changes in glutamatergic signaling are shared between or exclusive to specific psychostimulant drugs , we examined synaptic transmission from mice following repeated amphetamine or cocaine administration .
Synaptic transmission mediated by AMPA - type glutamate receptors was potentiated in the NAc shell 10–14 days following repeated amphetamine or cocaine treatment .
This synaptic enhancement was depotentiated by re - exposure to amphetamine or cocaine .
By contrast , in the NAc core only repeated cocaine exposure enhanced synaptic transmission , which was subsequently depotentiated by an additional cocaine but not amphetamine injection during drug abstinence .
Cocaine and Amphetamine Induce Overlapping but Distinct Patterns of AMPAR Plasticity in Nucleus Accumbens Medium Spiny Neurons .
To study whether changes in glutamatergic signaling are shared between or exclusive to specific psychostimulant drugs , we examined synaptic transmission from mice following repeated amphetamine or cocaine administration .
Repeated exposure to psychostimulant drugs such as cocaine or amphetamine can promote drug - seeking and -taking behavior .
By contrast , in the NAc core only repeated cocaine exposure enhanced synaptic transmission , which was subsequently depotentiated by an additional cocaine but not amphetamine injection during drug abstinence .
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