Cocaine addiction: psychology and neurophysiology.

  title={Cocaine addiction: psychology and neurophysiology.},
  author={Frank H. Gawin},
  volume={251 5001},
  • F. Gawin
  • Published 29 March 1991
  • Psychology, Biology
  • Science
Cocaine was considered incapable of producing dependence in 1980 but was recently proclaimed the drug of greatest national health concern. Recent clinical and preclinical investigations demonstrate that cocaine produces unique abuse and withdrawal patterns that differ from those of other major abused drugs and suggest that long-term cocaine abuse produces neurophysiological alterations in specific systems in the central nervous system that regulate the capacity to experience pleasure. It will… 

The Neurobiology of Cocaine

The abuse and addiction potential of cocaine results, at least partly, from its effects on specific neurotransmitter systems of the brain, and controlled studies have found that depressed or anxious people do not drink more than nondepressed or nonanxious individuals.

Neurophysiological effects of cocaine abstinence

Using electrophysiological recording procedures in behaving rodents, it is shown that Acb neurons encode information about key aspects of goal-directed behaviors and that cell firing in this region is sensitive to interruption (extinction) of response-reinforcement contingencies involving drug or natural rewards.

Prenatal Neurochemistry of Cocaine

  • J. Meyer
  • Biology, Chemistry
    Annals of the New York Academy of Sciences
  • 1992
The kinetic characteristics and prenatal ontogeny of cocaine binding sites in rat brain, and synaptosomal uptake of dopamine and the potency of cocaine in inhibiting such uptake during development are investigated.

Neurobehavioral Sequelae of Psychostimulant Abuse.

  • A. Djamshidian
  • Psychology, Biology
    International review of neurobiology
  • 2015

Neuropsychological deficits in abstinent cocaine abusers: preliminary findings after two weeks of abstinence.

Animal Models in Addiction Research

A number of animal models used in addiction research are reviewed and their relevance and explanatory utility to the different stages of the addiction cycle are discussed.

Electrophysiological correlates of abused drugs

  • S. Deadwyler
  • Psychology, Biology
    Annals of the New York Academy of Sciences
  • 2010
How abused drugs alter neuron firing in reward‐sensitive brain regions and how those alterations effect drug‐seeking activity in animals and humans is explored.

The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration

Cocaine Self-Administration Produces Long-Lasting Alterations in Dopamine Transporter Responses to Cocaine

It is determined that cocaine self-administration in rats produced tolerance to the dopamine transporter-inhibiting effects of cocaine in the nucleus accumbens core, which was normalized following a 14 or 60 d abstinence period, and reinstatement of cocaine tolerance was accompanied by decreased cocaine-induced locomotion and escalated cocaine intake despite extended abstinence from cocaine.

Dopaminergic agents for the treatment of cocaine abuse.




New concepts in cocaine addiction: The dopamine depletion hypothesis

Cocaine receptors on dopamine transporters are related to self-administration of cocaine.

It is shown here that the potencies of cocaine-like drugs in self-administration studies correlate with their potencies in inhibiting [3H]mazindol binding to the dopamine transporters in the rat striatum, but not with theirPotencies in binding to a large number of other presynaptic and postsynaptic binding sites.

Cocaine abuse treatment. Open pilot trial with desipramine and lithium carbonate.

Subjects who were treated with desipramine hydrochloride showed marked decreases in a measure of cocaine craving after two to three weeks of treatment and became abstinent regardless of whether an affective disorder was also present.

Amphetamine withdrawal: affective state, sleep patterns, and MHPG excretion.

The authors found that the clinical depressions which occurred following withdrawal from amphetamines after prolonged abuse were temporally associated with a decrease in the excretion of

Outpatient treatment of 'crack' cocaine smoking with flupenthixol decanoate. A preliminary report.

Promising but preliminary data, combined with the magnitude of problems presented by crack, warrant rapid, expanded double-blind assessment of flupenthixol decanoate in cocaine-abuse treatment.