Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature.

@article{Narendran2008CocaineAA,
  title={Cocaine abuse and sensitization of striatal dopamine transmission: a critical review of the preclinical and clinical imaging literature.},
  author={Rajesh Narendran and Diana Carolina Salamanca Martinez},
  journal={Synapse},
  year={2008},
  volume={62 11},
  pages={851-69}
}
Much effort has been devoted in the preclinical addiction literature to understanding the phenomenon of sensitization, an enhanced dopaminergic response in the nucleus accumbens that occurs after repeated exposure to psychostimulant drugs. Although sensitization has been reported in preclinical studies, studies of sensitization in humans measuring behavioral and physiological responses have been mixed and inconclusive. However, imaging studies with positron emission tomography (PET) and single… CONTINUE READING