Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis.

  title={Cocaine abuse and HIV-1 infection: epidemiology and neuropathogenesis.},
  author={Karl Goodkin and Paul Shapshak and Lisa R. Metsch and C B Mccoy and Keith A. Crandall and Manoj Kumar and Robert K. Fujimura and Virginia McCoy and Byoung Tak Zhang and S Reyblat and Ke Qin Xin and A. P. Mahesh Kumar},
  journal={Journal of neuroimmunology},
  volume={83 1-2},
The epidemiology of cocaine abuse and potential relationships of cocaine withdrawal to human immunodeficiency virus type 1 (HIV-1)-associated dementia (HAD) are discussed. Neuroendocrinological changes in HIV-1 infection of the central nervous system (CNS) are discussed with the relevant impact of cocaine abuse. HIV-1 load in the brain tissue of infected substance users is described along with possible associations with neuropathology and HAD. Finally, the molecular epidemiology and sequence… CONTINUE READING