Cocaine Withdrawal Causes Delayed Dysregulation of Stress Genes in the Hippocampus

Abstract

Relapse, even following an extended period of withdrawal, is a major challenge in substance abuse management. Delayed neurobiological effects of the drug during prolonged withdrawal likely contribute to sustained vulnerability to relapse. Stress is a major trigger of relapse, and the hippocampus regulates the magnitude and duration of stress responses… (More)
DOI: 10.1371/journal.pone.0042092

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