Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2

  title={Cocaine-Induced Chromatin Modifications Associate With Increased Expression and Three-Dimensional Looping of Auts2},
  author={Olivia Engmann and B. Labont{\'e} and Amanda Mitchell and P. Bashtrykov and E. Nestler},
  journal={Biological Psychiatry},
  • Olivia Engmann, B. Labonté, +2 authors E. Nestler
  • Published 2017
  • Biology, Medicine
  • Biological Psychiatry
  • BACKGROUND Exposure to drugs of abuse alters the epigenetic landscape of the brain's reward regions, such as the nucleus accumbens. We investigated how combinations of chromatin modifications affect genes that regulate responses to cocaine. We focused on Auts2, a gene linked to human evolution and cognitive disorders, which displays strong clustering of cocaine-induced chromatin modifications in this brain region. METHODS We combined chromosome conformation capture, circularized chromosome… CONTINUE READING
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