Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b

@inproceedings{Mantri2012CocaineEH,
  title={Cocaine Enhances HIV-1 Replication in CD4+ T Cells by Down-Regulating MiR-125b},
  author={Chinmay Kumar Mantri and Jui Pandhare Dash and Jyoti Velamarti Mantri and Chandravanu C. V. Dash},
  booktitle={PloS one},
  year={2012}
}
The main objective of this study was to examine effects of cocaine on HIV-1 replication in primary CD4+ T cells. Cocaine a commonly used drug among HIV-1 positive individuals serves as a cofactor for HIV-1 infection and progression to acquired immunodeficiency syndrome (AIDS). Accumulating evidence suggest that cocaine increases HIV-1 replication in cell cultures, peripheral blood mononuclear cells (PBMCs) and animal models. Intriguingly, there are no studies on cocaine-induced alterations in… CONTINUE READING
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