Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction

  title={Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction},
  author={N. Volkow and G. Wang and F. Telang and J. Fowler and J. Logan and Anna-Rose Childress and M. Jayne and Yeming Ma and C. Wong},
  journal={The Journal of Neuroscience},
  pages={6583 - 6588}
  • N. Volkow, G. Wang, +6 authors C. Wong
  • Published 2006
  • Medicine
  • The Journal of Neuroscience
  • The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their reinforcing effects. However, preclinical studies have shown that with repeated drug exposure neutral stimuli paired with the drug (conditioned stimuli) start to increase dopamine by themselves, which is an effect that could underlie drug-seeking behavior. Here we test whether dopamine increases occur to conditioned stimuli in human subjects addicted to cocaine and whether this is associated with drug… CONTINUE READING
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