Cocaine Constrictor Mechanisms of the Cerebral Vasculature.

  title={Cocaine Constrictor Mechanisms of the Cerebral Vasculature.},
  author={Robert M. Rapoport and Seonghun Yoon and Mario Zuccarello},
  journal={Journal of cardiovascular pharmacology},
  volume={67 5},
Cocaine constriction of the cerebral vasculature is thought to contribute to the ischemia associated with cocaine use. However, the mechanisms whereby cocaine elicits relevant vasoconstriction remain elusive. Indeed, proposed intra- and intercellular mechanisms based on over 3 decades of ex vivo vascular studies are, for the most part, of questionable relevancy due to the generally low contractile efficacy of cocaine combined with the use of nonresistance-type vessels. Furthermore, the… CONTINUE READING